HIV is grouped in the class of the retrovirus called lentivirus because it can be latent for a long period before serious symptoms of disease become manifest. HIV enters into the human immune system to locate and attack helper T-Cells that are produced from white blood cells. They include two main types of lymphocytes: T-cells and B cells. The virus gains entry into helper T-cell through the co-receptors on the T-cell and it immediately starts its reproductive sequence within the attacked T-cell. However, the genetic blueprint in HIV is in the form of RNA and not DNA---- This is where its weak point lies.
THE WEAKPOINT OF HIV
After thorough research, I found out that HIV has a weak point. The weak point is that it has no DNA but only RNA, and it is molecularly conditioned for every living thing to be genetically transformed from RNA to DNA before it can replicate for genetic decoding - irrespective of how small it is. Meanwhile, the HIV virus brilliantly manages its weak point by using a human T-cell’s DNA to churn out its RNA and protein during its second reproductive stage after it has been incorporated into human DNA in T-cell by integraze enzyme.
THE PROSPECT FOR AID’S CURE
The prospect for AIDS’ cure depends on the concept of the weakness of the HIV virus explained above. HIV virus attacks T-Cells when it enters into one, and its single strand RNA is converted into double strand by Reverse transcriptase (RT) enzyme (1st reproductive stage). It is then incorporated into the T-cell’s DNA by intergraze and uses the DNA and the manufacturing process of T-cell to churn out its RNA and proteins for genetic decoding. However, the prospect for AIDS’ cure is found in the inability of HIV to be capable on its own to change its own RNA to DNA without the help of T-cell’s mechanism.
METHOD
The inhibiting drugs should be designed to prevent the HIV from using the T-cell’s mechanism to further its own end; the drug should be designed in such a way to prevent or inhibit HIV to change its own RNA into DNA so that its code could not be read and understood by the host T -cell’s machinery.
Hence, the virus would not be able to churn out its RNA and proteins that should be cut into shorter pieces by the enzyme called protease [in the last stage of its reproductive sequence] and the cut shorter pieces would not be able to develop into numerous replicates that would affect and start another life cycle in other T-cells.
CONCLUSION
The solution to the AIDS epidemics is relevant to this weak point of the HIV Virus.
Once the virus could be disrupted from passing across its code, so that it could not be read and understood by the host T-Cell mechanism, it would not be able to use human T-Cell’s DNA to churn out its RNA and proteins. It would be difficult for the virus to reprogram the DNA of the T-cell to make many copies of HIV that would affect the other T-cells. Hence, its life cycle is disturbed, the human immune system is empowered and AIDS is halted.
Note: This research work is the copyright of my work: Olawuyi Oluwafemi Iwaloye ©
NAME: Olawuyi Oluwafemi Iwaloye
STATUS: Undergraduate [BMLS]-Medical Science
OCCUPATION: Independent Researcher
ADDRESS: No. 2, Sabo Road, Mokola Roundabout (Opposite St. Lawrence Hospital), Ibadan, Oyo State, Nigeria.
E-MAIL: drgrsb@yahoo.com
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